Disruption is taking hold of health care, with major retail pharmacy chains, payers, technology companies, and others making their presence felt. In the race to transform care delivery, reduce health care costs and improve access to meet consumer expectations, this is a defining moment. This lecture examines some of the key strategic moves by Amazon, CVS Health, Walgreens, Best Buy, and Walmart. Together we’ll speculate how these strategies may play out in the months and years ahead.